Serotonin release by parachloroamphetamine in rats with high and low sociability: High prefrontal release capacity in sociable females

• Published in: Journal of psychopharmacology (Oxford) Vol. 38; no. 11; pp. 1016 - 1024
• Main Authors: Norden, Marianna, Kanarik, Margus, Laugus, Karita, O’Leary, Aet, Liiver, Kristi, Tõnissaar, Margus, Shimmo, Ruth, Harro, Jaanus
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-11-2024; Sage Publications Ltd
• Subjects: Drug delivery; Extracellular levels; Females; Microdialysis; Neostriatum; Neurotransmission; Original Papers; p-Chloroamphetamine; Prefrontal cortex; Serotonin; Social behavior; Social interaction; Ventral tegmentum; anxiety; serotonin release; microdialysis; 5-hydroxytryptamine; dopamine release; p-chloroamphetamine; Sociability
• ISSN: 0269-8811; 1461-7285; 1461-7285
• DOI: 10.1177/02698811241283710

Background:
Social behaviour is the expression of one of the most generally accepted independent dimensions of personality. Serotonergic neurotransmission has been implicated in typical social response and drugs that promote serotonin (5-hydroxytryptamine (5-HT)) release have prosocial effects. By using the social interaction test, we have previously demonstrated sociability as a temperamental trait in male Wistar rats.
Aims:
To assess sociability in male rats of the Sprague–Dawley strain and in female rats of both Wistar and Sprague–Dawley strain, and extracellular levels of 5-HT in rats with high and low sociability (high sociability (HS)- and low sociability (LS)-rats).
Methods:
Social interaction test conducted with different weight-matched partners was used to assess sociability, and in vivo, microdialysis was performed before and after administration of a low dose (2 mg/kg) of parachloroamphetamine (PCA) in the prefrontal cortex, dorsamedial striatum and ventral tegmental area.
Results:
Similarly to male Wistar rats, female Wistars and Sprague–Dawley rats of both sexes displayed trait-wise sociability. Male Wistar HS-rats had lower extracellular levels of 5-HT in prefrontal cortex at baseline and after administration of PCA, and higher PCA-induced increase of extracellular 5-HT in ventral tegmental area. In dorsomedial striatum, PCA elicited a comparable increase in extracellular dopamine in HS- and LS-rats, but higher release of 5-HT in HS-rats. Comparison of PCA-induced 5-HT release in prefrontal cortex of male and female Sprague–Dawley rats revealed a larger 5-HT response in female HS-rats.
Conclusions:
5-HT release potential is higher in rats with high expression of sociability trait, whereas some regionally variable differences may be related to relative contributions of social motivation and anxiety in shaping social behaviour.