Efficient synthesis of arylsulfamides by reaction of amines with arylsulfamoyl imidazolium triflate

Arylsulfamoyl imidazolium triflates, readily prepared from the corresponding chlorides, react with amines under neutral conditions to form arylsulfamides in high yields. This methodology, which contrasts with the slow and inefficient reactions of amines with arylsulfamoyl chlorides, is applied to th...

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Bibliographic Details
Published in:	Tetrahedron letters Vol. 46; no. 42; pp. 7139 - 7142
Main Authors:	Lee, Hyeon Kyu, Bang, Miyeon, Pak, Chwang Siek
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 17-10-2005
Subjects:	Arylsulfamide Arylsulfamoyl chloride Arylsulfamoyl imidazolium triflate PPAR agonist Arylsulfamide Arylsulfamoyl imidazolium triflate Arylsulfamoyl chloride PPAR agonist
Online Access:	Get full text
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Summary:	Arylsulfamoyl imidazolium triflates, readily prepared from the corresponding chlorides, react with amines under neutral conditions to form arylsulfamides in high yields. This methodology, which contrasts with the slow and inefficient reactions of amines with arylsulfamoyl chlorides, is applied to the synthesis of arylsulfamide 3a , a bioisotere of muraglitazar.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2005.08.092