An efficient copper(I) complex catalyzed Sonogashira type cross-coupling of aryl halides with terminal alkynes

• Published in: Tetrahedron letters Vol. 50; no. 24; pp. 2865 - 2869
• Main Authors: Thakur, K.G., Jaseer, E.A., Naidu, Ajay B., Sekar, Govindasamy
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 17-06-2009
• Subjects: Arylated alkynes; Copper catalyst; Coupling reaction; C–C bond formation; Sonogashira coupling; Arylated alkynes; Sonogashira coupling; Copper catalyst; Coupling reaction; C–C bond formation
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2009.03.146

A wide range of arylated alkynes are synthesized from the corresponding aryl halides and terminal alkynes by Sonogashira type cross-coupling reactions through C(aryl)–C bond formation in the presence of a catalytic amount of
N,
N′-dibenzyl BINAM–CuI complex under mild reaction conditions.
A wide range of arylated alkynes are synthesized from the corresponding aryl halides and terminal alkynes through Sonogashira type cross-coupling reactions through C(aryl)–C bond formation in the presence of a catalytic amount of
N,
N′-dibenzyl BINAM–CuI complex under mild reaction conditions.