Automated radiosynthesis of [ 11 C]CPPC for in-human PET imaging applications

• Published in: American journal of nuclear medicine and molecular imaging Vol. 14; no. 2; pp. 144 - 148
• Main Authors: Jiang, Huailei, Roy, Pritam, Guo, Yan, Muzik, Otto, Woodcock, Eric A
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01-01-2024
• Subjects: Original; radiosynthesis; automation; PET imaging; [11C]CPPC; radiopharmaceutical
• ISSN: 2160-8407; 2160-8407
• DOI: 10.62347/MXKZ6739

The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of microglia availability. [
C]CPPC has specific binding affinity to CSF1R and suitable kinetic properties for
PET imaging of microglia. However, previous studies reported a low radiochemical yield, motivating additional research to optimize [
C]CPPC radiochemistry. In this work, we report an automated radiosynthesis of [
C]CPPC on a Synthra MeIPlus module with improved radiochemical yield. The final [
C]CPPC product was obtained with excellent chemical/radiochemical purities and molecular activity, facilitating high-quality in-human PET imaging applications.