A multianalyte electrochemical sensor based on cellulose fibers with silver nanoparticles composite as an innovative nano-framework for the simultaneous determination of ascorbic acid, dopamine and paracetamol

• Published in: Surfaces and interfaces Vol. 26; p. 101377
• Main Authors: Santhosh, A.S., Sandeep, S., James Bound, D., Nandini, S., Nalini, S., Suresh, G.S., Swamy, N. Kumara, Rajabathar, Jothi Ramalingam, Selvaraj, Arokiyaraj
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-10-2021
• Subjects: AgNPs; Cellulose nanofibres; Dopamine; Paracetamol; voltametry; AgNPs; Cellulose nanofibres; Paracetamol; Dopamine; voltametry
• ISSN: 2468-0230; 2468-0230
• DOI: 10.1016/j.surfin.2021.101377

In the current study, we have developed a voltammetric biosensor using cellulose nano-fibers (CNF's) and silver nanoparticles (AgNPs) for concomitant determination of ascorbic acid (AA), dopamine (DA) and paracetamol (PA). CNFs were extracted from sugar cane bagasse as a natural source and percentage of bleached cellulose in CNF was found to be 84.12%, with significant increase in cellulose content following the chemical treatment. AgNPs was synthesised in situ using CNFs as a reducing agent. The average domain size of nanoparticles and degree of crystallinity of the extracted fibres was determined to be 15.3 nm and 79.23% respectively.
The AgNPs-CNFs innovative nano framework composite was employed in the fabrication of the multi-analyte electrochemical sensor and electro analytical characterization performed with cyclic voltametry (CV) and differential pulse voltammetry (DPV). The proposed Gr/CNF-AgNPS (Graphite/Cellulose nanofibers-silver nano particles) nanocomposite electrode exhibited large surface area and high selectivity, wide linear responses with a very low analysis/determination limits of 0.029,0.034 and 0.019 µmol/L for AA, DA and PA, respectively. The developed electrode demonstrated exceptional anti-interference property. Furthermore, the proposed sensor was successfully employed for the analysis of AA, DA and PA in human urine and blood serum.