Supercritical fluid chromatography for the 21st century

• Published in: The Journal of supercritical fluids Vol. 47; no. 3; pp. 566 - 573
• Main Author: Taylor, Larry T.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2009
• Subjects: Capillary columns; Chiral separations; Mass spectrometry; Packed columns; Preparative scale separations; Simulated moving bed; Supercritical fluid chromatography; Capillary columns; Packed columns; Chiral separations; Simulated moving bed; Preparative scale separations; Mass spectrometry; Supercritical fluid chromatography
• ISSN: 0896-8446; 1872-8162
• DOI: 10.1016/j.supflu.2008.09.012

A brief historical review of supercritical fluid chromatography (SFC) as it pertains to open tubular (i.e. capillary) column SFC and packed column SFC is presented. Specific sections include (1) early emphasis on open tubular columns and non-polar analytes; (2) packed column SFC for separation of more polar analytes; (3) preparative scale packed column SFC. The review is completed by discussing current trends in SFC such as (a) chiral separations, (b) achiral separations, (c) simulated moving bed SFC, and (d) SFC coupled to mass spectrometry.
A brief historical review of supercritical fluid chromatography (SFC) as it pertains to open tubular (i.e. capillary) column SFC and packed column SFC is presented. Specific sections include (1) early emphasis on open tubular columns and non-polar analytes; (2) packed column SFC for separation of more polar analytes; (3) preparative scale packed column SFC. The review is completed by discussing current trends in SFC such as (a) chiral separations, (b) achiral separations, (c) simulated moving bed SFC, and (d) SFC coupled to mass spectrometry.