Grinding induced catalyst free, multicomponent synthesis of Indoloindole pyrimidine

Grinding induced catalyst free, multicomponent synthesis of Indoloindole pyrimidine

[Display omitted] •Liquid assisted hand grinding.•Pure product without column chromatography.•High yield.•Metal free synthesis. A simple, efficient, environmentally friendly, and ethanol assisted mechanochemical approach for the synthesis of Indoloindole pyrimidine has been developed through a simpl...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 61; no. 41; p. 152383
Main Authors: Maury, Suresh Kumar, Kumari, Savita, Kushwaha, Ambuj Kumar, Kamal, Arsala, Singh, Himanshu Kumar, Kumar, Dhirendra, Singh, Sundaram
Format: Journal Article
Language:English
Published: Elsevier Ltd 08-10-2020
Subjects:
Green
Grinding
Indoloindole pyrimidine
Mechanochemical
Multicomponent reaction
Mechanochemical
Multicomponent reaction
Grinding
Indoloindole pyrimidine
Green
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Summary:[Display omitted] •Liquid assisted hand grinding.•Pure product without column chromatography.•High yield.•Metal free synthesis. A simple, efficient, environmentally friendly, and ethanol assisted mechanochemical approach for the synthesis of Indoloindole pyrimidine has been developed through a simple mortar and pestle under catalyst-free grinding method. The present protocol is green and associated with easy workup step, high yield of product, short reaction time, and bear an extensive range of functional groups.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2020.152383