Direct oxidative cyclization of 3-arylpropionic acids using PIFA or Oxone: synthesis of 3,4-dihydrocoumarins
The direct oxidative cyclization of 3-arylpropionic acids using PIFA or Oxone is reported. In the presence of BF 3·OEt 2, the reaction of 3-arylpropionic acids with PIFA or Oxone proceeded smoothly at 30 °C to give 3,4-dihydrocoumarins in good to excellent yields.
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| Published in: | Tetrahedron letters Vol. 51; no. 1; pp. 192 - 196 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
06-01-2010
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| Online Access: | Get full text |
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| Summary: | The direct oxidative cyclization of 3-arylpropionic acids using PIFA or Oxone is reported. In the presence of BF
3·OEt
2, the reaction of 3-arylpropionic acids with PIFA or Oxone proceeded smoothly at 30
°C to give 3,4-dihydrocoumarins in good to excellent yields. |
|---|---|
| ISSN: | 0040-4039 1873-3581 |
| DOI: | 10.1016/j.tetlet.2009.10.112 |