An acetohydroxamate-coordinated oxidovanadium(V) complex derived from pyridinohydrazone ligand with urease inhibitory activity

• Published in: Inorganic chemistry communications Vol. 105; pp. 212 - 216
• Main Authors: Li, Yanmin, Xu, Luyao, Duan, Mengmeng, Wu, Jiahui, Wang, Yinghui, Dong, Kexin, Han, Moxuan, You, Zhonglu
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-07-2019
• Subjects: Acetohydroxamate; Crystal structure; Oxidovanadium(V) complex; Pyridinohydrazone; Urease inhibition; Urease inhibition; Oxidovanadium(V) complex; Acetohydroxamate; Pyridinohydrazone; Crystal structure
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2019.05.011

A new acetohydroxamate coordinated oxidovanadium(V) complex derived from the pyridinohydrazone ligand 2′-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L), was prepared and characterized by elemental analysis, IR, UV–vis and 1H NMR spectra, and single crystal X-ray diffraction. Thermal analysis of the complex was performed. The V atom is in octahedral coordination. The complex has remarkable inhibitory activity on Jack bean urease with IC50 value of 14.9 μmol·L−1. The interaction mode of the complex with the urease was studied by molecular docking technique.
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•A new acetohydroxamate coordinated oxidovanadium(V) complex was prepared.•The complex has been characterized by single crystal X-ray diffraction.•The complex shows strong urease inhibitory activity.