Synthesis and derivatisation of N, N′-trisubstituted 1,2-diamines derived from (1 R,2 R)-1,2-diaminocyclohexane

Synthesis and derivatisation of N, N′-trisubstituted 1,2-diamines derived from (1 R,2 R)-1,2-diaminocyclohexane

[Display omitted] The synthesis of N, N′-trisubstituted 1,2-diamines can be achieved by simple reduction of an aminal derived from (1 R,2 R)-diaminocyclohexane. We comment on the scope and limitation of this reduction and discuss its application towards the synthesis of unsymmetrical N, N′-tetrasubs...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 46; no. 20; pp. 3479 - 3484
Main Authors: Boyd, Ewan, Coumbarides, Gregory S., Eames, Jason, Jones, Ray V.H., Stenson, Rachel A., Suggate, Michael J.
Format: Journal Article
Language:English
Published: Elsevier Ltd 16-05-2005
Online Access:Get full text
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Summary:[Display omitted] The synthesis of N, N′-trisubstituted 1,2-diamines can be achieved by simple reduction of an aminal derived from (1 R,2 R)-diaminocyclohexane. We comment on the scope and limitation of this reduction and discuss its application towards the synthesis of unsymmetrical N, N′-tetrasubstituted 1,2-diamines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.03.129