Thermo-acoustic approach for pesticide-plasma protein binding in colloidal system: An impact of membrane mimic structures on molecular interactions in biological systems

• Published in: Journal of molecular liquids Vol. 385; p. 122344
• Main Authors: Arif, Iqra, Naseem, Bushra, Yaseen Khan, Ather, Shujaat, Shahida
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-09-2023
• Subjects: Human serum albumin; Ionic surfactants; Molecular interactions; Organophosphate pesticides; Volumetric and acoustic parameters; Volumetric and acoustic parameters; Human serum albumin; Ionic surfactants; Organophosphate pesticides; Molecular interactions
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2023.122344

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•Effect of colloids on interactions among plasma protein and organophosphate pesticides.•Molecular interactions in biological system in terms of thermo-acoustic parameters.•Temperature controlled molecular interactions of pesticides in plasma protein solutions.•Structure making behavior of pesticides molecules in their solutions.•Positive values of Vϕ suggested strong molecular interactions in solutions.
Recently, use of agrochemicals, most importantly pesticides has experienced an enormous upsurge as a consequence of continuously increasing demand of enhanced crop production. Various toxins in the environment interact with bio-molecules and causes serious ailments in human beings. Different physicochemical, computational and spectroscopic methods have been used to study binding of toxins with bio-molecules. In present study, thermo-acoustic method was aimed to employ for studying binding of organophosphate pesticides with plasma protein in absence and presence of colloidal solutions of ionic surfactants. Role of different binding sites in protein molecules, nature of pesticide molecules and forces involved in pesticide-plasma protein binding were investigated. Volumetric and acoustic parameters such as apparent (Vϕ) and partial molar volume (Voϕ), expansibility factor (Eoϕ), Hepler’s constant, compressibility factor (Kϕ) and intermolecular free length (Lf) were calculated using density and sound velocity data at different temperatures (293.15–313.15)K. Positive values of Vϕ increased with increasing pesticide concentration in aqueous plasma protein solutions which were indicative of strong associative molecular interactions in solutions. Obtained results of this study about pesticides-protein binding will be helpful for medical and pharmaceutical researchers.