A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction

A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction

A convenient method for double Michael additions to quinone systems catalyzed by Al 2O 3, is reported. The advantages of this method include the use of a cheap and environment-friendly catalyst, a straightforward isolation of the pure product by filtration, high yields, and excellent selectivity, th...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 49; no. 4; pp. 583 - 585
Main Authors: Castellano, Sabrina, Bertamino, Alessia, Gomez-Monterrey, Isabel, Santoriello, Marisabella, Grieco, Paolo, Campiglia, Pietro, Sbardella, Gianluca, Novellino, Ettore
Format: Journal Article
Language:English
Published: Elsevier Ltd 21-01-2008
Subjects:
Eco-friendly heterogeneous catalysts
Michael addition
Quinone-containing antitumoral drugs
Michael addition
Quinone-containing antitumoral drugs
Eco-friendly heterogeneous catalysts
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Summary:A convenient method for double Michael additions to quinone systems catalyzed by Al 2O 3, is reported. The advantages of this method include the use of a cheap and environment-friendly catalyst, a straightforward isolation of the pure product by filtration, high yields, and excellent selectivity, thus providing rapid access to useful building blocks for the preparation of biologically active quinones.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.11.148