A flavonoid with cytotoxic activity and other constituents from Centaurea africana

• Published in: Phytochemistry letters Vol. 2; no. 3; pp. 114 - 118
• Main Authors: Seghiri, Ramdane, Boumaza, Ouahiba, Mekkiou, Ratiba, Benayache, Samir, Mosset, Paul, Quintana, José, Estévez, Francisco, León, Francisco, Bermejo, Jaime, Benayache, Fadila
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 24-08-2009
• Subjects: Acylated flavonoid glucoside; Algerianin; Asteraceae; Centaurea africana; Cytotoxic activity; HL-60 cells; Human leukaemia cell line; Centaurea africana; Algerianin; Human leukaemia cell line; Asteraceae; Acylated flavonoid glucoside; HL-60 cells; Cytotoxic activity
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2009.03.002

A new acylated flavonoid glucoside named algerianin
1 and a new natural product, 4′-methyl gossypetin, together with 10 known compounds, were isolated from
Centaurea africana Lamk var.
africana (Bonnet) M. Algerianin showed cytotoxicity against the human myeloid leukaemia cell line HL-60.
A new acylated flavonoid glucoside named algerianin
1 and a new as natural product, 4′-methyl gossypetin
2, together with 10 known compounds, isovanillic acid ethyl ester, β-sitosterol, β-sitosterol 3-
O-glucoside, a mixture of α and β-amyrin, 3′-hydroxyflindulatin, chrysoeriol, jaceidin, corniculatusin and centaurein were isolated from the ethanolic extract of the flowering and aerial parts of
Centaurea africana Lamk var.
africana (Bonnet) M., an endemic species to Algeria and Tunisia collected from El-Kala in the eastern Algeria. The structures were established by chemical and spectral analysis, mainly HREIMS, ESIMS, UV and NMR experiments (GOESY, COSY, ROESY, HSQC and HMBC). Algerianin showed cytotoxicity against the human myeloid leukaemia cell line HL-60.