The physicochemical and biological properties of zinc(II) complexes

• Published in: Journal of thermal analysis and calorimetry Vol. 88; no. 2; pp. 355 - 361
• Main Authors: SZUNYOGOVA, Erika, MUDRONOVA, Dagmar, GYÖRYOVA, Katarina, NEMCOVA, Radomira, KOVAROVA, Jana, PIKNOVA-FINDORAKOVA, Lenka
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Dordrecht Springer 01-05-2007
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; General aspects; Medical sciences; Pharmacology. Drug treatments; Zn(II); Divalent metal Complexes; Salmonella; Transition element complexes; Lactobacillus plantarum; Zinc II Complexes; Escherichia coli; Antiasthma agent; Antimicrobial agent; Respiratory analeptic; Pyrazole derivatives; Bacteria; Lactobacillaceae; Micrococcales; Micrococcaceae; Xanthine derivatives; IR spectra; Phenazone; Chemical synthesis; Staphylococcus aureus; Enterobacteriaceae; Lactobacillus fermentum; Bronchodilator; Thermogravimetry; Organic ligand; antimicrobial activity; In vitro; Biological activity; Thermal properties; Infrared spectrometry; Analgesic; Antipyretic; Carboxylate; Formate; Thermal analysis; Theophylline; complexes
• ISSN: 1388-6150; 1588-2926; 1572-8943
• DOI: 10.1007/s10973-006-8115-z

Spectroscopic (IR), thermoanalytical (TG/DTG, DTA) and biological methods were applied to investigate physicochemical and biological properties of seven zinc(II) complex compounds of the following formula Zn(HCOO)2*2H2O (I), Zn(HCOO)2*tph (II), Zn(CH3COO)2*2H2O (III), Zn(CH3COO)2*tph (IV), Zn(CH3COO)2*2phen (V), Zn(CH3CH2COO)2*2H2O (VI), Zn(CH3CH2CH2COO)2*2H2O (VII), where tph=theophylline, phen=phenazone. The formation of various intermediates during thermal decomposition suggests the dependence on the length of aliphatic carboxylic chain and type of N-donor ligand (tph, phen). The final product of the thermal decomposition was ZnO. The antimicrobial activity of these complexes were tested against G and G bacteria. Strong inhibitive effect was observed towards E. coli, salmonellae and Staph. aureus.