Synthesis of triazolo indazolones using 3D mesoporous aluminosilicate catalyst with nanocage structure

• Published in: Tetrahedron letters Vol. 51; no. 19; pp. 2629 - 2632
• Main Authors: Adharvana Chari, M., Karthikeyan, G., Pandurangan, A., Siddulu Naidu, T., Sathyaseelan, B., Javaid Zaidi, S.M., Vinu, A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 12-05-2010
• Subjects: AlKIT-5; Aromatic aldehyde; Dimedone; Indazole-1,3,8-trione derivatives; One-pot condensation; Urazole; AlKIT-5; Urazole; Dimedone; Aromatic aldehyde; Indazole-1,3,8-trione derivatives; One-pot condensation
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2010.03.021

Mesoporous aluminosilicate (AlKIT-5) has been found to be an efficient catalyst for one-pot synthesis of triazolo[1,2-
a]indazole-1,3,8-trione derivatives from dimedone, urazole, and aromatic aldehydes using acetonitrile as a solvent. This new method is simple, effective, ecofriendly, and consistently has the advantage of excellent yields (80–96%) and short reaction time (30–60
min). The effect of the catalyst weight, aluminum content in the catalyst, and the solvents on the synthesis of triazolo[1,2-
a]indazole-1,3,8-trione derivatives has been investigated. It has been found that the catalyst can be recycled for several times without much affecting its activity for a variety of organic transformations.
Mesoporous Aluminosilicate (AlKIT-5) has been found to be an efficient catalyst for one-pot synthesis of triazolo[1,2-a]indazole-1,3,8-trione derivatives from dimedone, urazole, and aromatic aldehydes using acetonitrile as a solvent. This new method is simple, effective, ecofriendly, and consistently has the advantage of excellent yields (80–96%) and short reaction time (30–60
min). The effect of the catalyst weight, aluminum content in the catalyst, and the solvents on the synthesis of triazolo[1,2-
a]indazole-1,3,8-trione derivatives has been investigated. It has been found that the catalyst can be recycled for several times without much affecting its activity for a variety of organic transformations.