A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methods

• Published in: International journal of circumpolar health Vol. 64; no. 3; pp. 206 - 221
• Main Authors: Howard, Barbara V., Devereux, Richard D., Cole, Shelley A., Davidson, Michael, Dyke, Bennett, Ebbesson, Sven O. E., Epstein, Stephen E., Robinson, David R., Jarvis, Betty, Kaufman, David J., Laston, Sandra, MacCluer, Jean W., Okin, Peter M., Roman, Mary J., Romenesko, Terry, Ruotolo, Giacomo, Swenson, Michael, Wenger, Charlotte R., Williams-Blangero, Sarah, Zhu, Jianhui, Saccheus, Clarence, Fabsitz, Richard R., Robbins, David C.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01-07-2005
• Subjects: Adult; Aged; Alaska - epidemiology; Cardiovascular Diseases - ethnology; Cardiovascular Diseases - genetics; diabetes; Epidemiologic Research Design; epidemiology; Female; Genetic Predisposition to Disease - ethnology; genetics; Genotype; heart disease; Humans; Hypertension; Inflammation Mediators - blood; Inuit Eskimo; Inuits; Life Style - ethnology; Longitudinal Studies; Male; Middle Aged; Pedigree; Population Surveillance - methods; Risk Factors; vascular disease; Alaska
• ISSN: 1239-9736; 2242-3982; 2242-3982
• DOI: 10.3402/ijch.v64i3.17985

This article is a report of the design and methods of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study. This longitudinal, population-based study was initiated to investigate the genetic determinants of cardiovascular disease and its risk factors. Between October 2000 and April 2004, this family study enrolled 1,214 Eskimos from several coastal villages in the Norton Sound region of Western Alaska. Examinations included a physical, laboratory determinations, and measures of subclinical disease. This study will generate a genome-wide scan for loci influencing cardiovascular disease-related traits. Relations between subclinical atherosclerosis and markers of inflammation will be examined using historic and newly drawn samples. The study will provide data on CVD prevalence, risk factors and the relative contribution of genetic and environmental determinants in Alaska Native peoples. Data from this study will contribute to the delivery of health-care and prevention of CVD in Alaska Eskimos and other populations. (Int J Circumpolar Health 2005; 64(3):206-221)