Spectrophotometric Determination of Sodium Mercaptoundecahydrododecaborate with 5, 5′-Dithiobis(2-nitrobenzoic acid)

• Published in: Analytical Sciences Vol. 3; no. 6; pp. 561 - 564
• Main Authors: IKEUCHI, Isao, AMANO, Tameyuki
• Format: Journal Article
• Language: English
• Published: Tokyo The Japan Society for Analytical Chemistry 10-12-1987; Japan Society for Analytical Chemistry; Japan Science and Technology Agency
• Subjects: 5,5′-dithiobis(2-nitrobenzoic acid); Applied sciences; boron neutron-capture therapy; Exact sciences and technology; Other techniques and industries; Sodium mercaptoundecahydrododecaborate; spectrophotometry
• ISSN: 0910-6340; 1348-2246
• DOI: 10.2116/analsci.3.561

A simple, sensitive and accurate method for the determination of sodium mercaptoundecahydrododecaborate, Na210B12H11SH, which is one of the most useful agents for boron neutron-capture therapy of brain tumors, was developed by spectrophotometry with 5, 5′-dithiobis(2-nitrobenzoic acid) [DTNB]. The color development based on 2-nitro-5-mercaptobenzoic acid liberated from DTNB by an exchange reaction of the sulfhydryl group showed maximal absorbance at 398nm with 1.65×104dm3 mol-1 cm-1. Beer′s law was obeyed up to 6×10-4mol dm-3. The detection limit was 2×10-5mol dm-3.