Immunization of the neonate

The generation of diversity of T and B cells begins early in gestation. Selective restrictions in expression of V genes occur in fetal life, but insufficient clonal diversity is not likely to limit newborn immune capabilities. The functional immaturity of neonatal T and B cells is beginning to be de...

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Bibliographic Details
Published in:	International journal of technology assessment in health care Vol. 10; no. 1; p. 154
Main Author:	Lawton, A R
Format:	Journal Article
Language:	English
Published:	England 1994
Subjects:	Age Factors Antibody Diversity - immunology B-Lymphocytes - immunology Fetus - immunology Gene Expression Regulation - immunology Humans Immunization - methods Infant, Newborn - immunology Lymphokines - immunology Plasma Cells - immunology T-Lymphocytes - immunology
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Summary:	The generation of diversity of T and B cells begins early in gestation. Selective restrictions in expression of V genes occur in fetal life, but insufficient clonal diversity is not likely to limit newborn immune capabilities. The functional immaturity of neonatal T and B cells is beginning to be defined. Virgin T cells lack the capacity to produce diverse lymphokines, whereas neonatal B cells are less responsive to the lymphokines that promote terminal differentiation to plasma cells.
ISSN:	0266-4623
DOI:	10.1017/S0266462300014070