Probing pharmaceutically important amino acids L-isoleucine and L-tyrosine Solubilities: Unraveling the solvation thermodynamics in diverse mixed solvent systems

• Published in: Biophysical chemistry Vol. 309; p. 107229
• Main Authors: Chakraborty, Jit, Mahali, Kalachand, Henaish, A.M.A., Ahmed, Jahangeer, Alshehri, Saad M., Roy, Sanjay
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-06-2024
• Subjects: Amino acids; Binary solvent systems; Solubility; Solvent-solvent interactions; Thermodynamic properties; Solvent-solvent interactions; Amino acids; Binary solvent systems; Thermodynamic properties; Solubility
• ISSN: 0301-4622; 1873-4200
• DOI: 10.1016/j.bpc.2024.107229

The study specifically investigates the solubilities of L-isoleucine and L-tyrosine in water-mixed solvent systems (DMF, DMSO, and ACN), exploring the behaviour of amino acids in complex environments. The experimental methods prioritize meticulous solvent purification to ensure reliable results. The work explores solubility data, uncovering temperature-dependent trends and intricate interactions influencing solubility in the chosen mixed solvent systems. The study emphasizes the impact of thermodynamic properties, solvent-solvent interactions, and amino acid structure on solubility patterns. The broader implications highlight the relevance of understanding amino acid behaviour in diverse solvent environments, offering potential applications in cosmetics and pharmaceutical industries. The distinct solubility patterns contribute valuable insights, enhancing on the understanding of the solution stability and interactions of L-isoleucine and L-tyrosine in different solvent systems. In conclusion, work suggests the enhanced utilization of L-isoleucine and L-tyrosine in various industries, driven by a profound understanding of their solubility in mixed solvent systems. The research expands our knowledge of amino acid behaviour, paving the way for advancements in industries relying on protein-based products and technologies.
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•Solubilities of L-isoleucine and L-tyrosine studied in DMF, DMSO, and ACN mixed solvent systems.•Temperature-dependent trends and intricate interactions influence solubility.•Contributes distinct solubility patterns, expanding knowledge for protein-based product advancements.•Thermodynamic properties, solvent-solvent interactions, and amino acid structure impact solubility.