Differential effects of haloperidol on neural oscillations during wakefulness and sleep

• Published in: Neuroscience Vol. 560; pp. 67 - 76
• Main Authors: Gallo, Diego, Cavelli, Matias, Castro-Zaballa, Santiago, Castro-Nin, Juan Pedro, Pascovich, Claudia, Torterolo, Pablo, González, Joaquín
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12-11-2024
• Subjects: 1/f; Alpha; Aperiodic Activity; Dopamine; Gamma; Neural Oscillations; Power Spectra; Sleep; Gamma; Aperiodic Activity; Dopamine; Sleep; 1/f; Alpha; Neural Oscillations; Power Spectra
• ISSN: 0306-4522; 1873-7544; 1873-7544
• DOI: 10.1016/j.neuroscience.2024.09.020

•Brain activity includes both oscillatory and aperiodic components.•Dopamine may modulate these components differently.•Haloperidol influences oscillatory, but not aperiodic, activity.•Oscillatory activity modulation occurs across the brain.
The electrical activity of the brain, characterized by its frequency components, reflects a complex interplay between periodic (oscillatory) and aperiodic components. These components are associated with various neurophysiological processes, such as the excitation-inhibition balance (aperiodic activity) or interregional communication (oscillatory activity). However, we do not fully understand whether these components are truly independent or if different neuromodulators affect them in different ways. The dopaminergic system has a critical role for cognition and motivation, being a potential modulator of these power spectrum components. To improve our understanding of these questions, we investigated the differential effects of this system on these components using electrocorticogram recordings in cats, which show clear oscillations and aperiodic 1/f activity. Specifically, we focused on the effects of haloperidol (a D2 receptor antagonist) on oscillatory and aperiodic dynamics during wakefulness and sleep. By parameterizing the power spectrum into these two components, our findings reveal a robust modulation of oscillatory activity by the D2 receptor across the brain. Surprisingly, aperiodic activity was not significantly affected and exhibited inconsistent changes across the brain. This suggests a nuanced interplay between neuromodulation and the distinct components of brain oscillations, providing insights into the selective regulation of oscillatory dynamics in awake states.