Integration of a facile sustainable resonance Rayleigh scattering switchable-based system for feasible determination of centrophenoxine, a nootropic and antioxidant agent; application to crude materials and dosage forms

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 313; p. 124107
• Main Authors: Abdulhafez Hamad, Ahmed, Mahdi, Wael A., Alshehri, Sultan, Soltan, Osama M., Abdelrahman, Kamal S., Abdel-Aal, Mohamed A.A., Saad Al-Farhan, Badriah, Maslamani, Nujud, Saleh, Safaa F., El Hamd, Mohamed A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15-05-2024
• Subjects: Centrophenoxine. HCl; Erythrosine B food dye; Resonance Rayleigh Scattering switchable system; Sustainable chemistry; Whiteness and greenness evaluation; Centrophenoxine. HCl; Erythrosine B food dye; Resonance Rayleigh Scattering switchable system; Whiteness and greenness evaluation; Sustainable chemistry
• ISSN: 1386-1425
• DOI: 10.1016/j.saa.2024.124107

A simple scheming summarizing the planned method and giving overall picture about the article concerns, CPX-Erythrosine B coupled product suggested mechanism, system spectra, and method's greenness and whitness evaluation.
[Display omitted]
•The article introduces a facile green/white/blue spectroscopic method to analyze the CPX drug.•The method lacks the extraction process, reduced analysis time, and reduced cost.•The article presents a dye-drug product that relied on the RRS response strategy.•The method was applied to determine the drug in its raw and dosage forms.•The system was validated and studied from the greenness, whiteness, and blueness viewpoints using various tools.
The proposed research adheres to a certain methodology to ensure that the technique used for analyzing the centrophenoxine drug is sustainable and green. It is important to highlight that several tools that have been recently developed were utilized as potential indicators of environmental sustainability and applicability. The present research presents a novel and entirely innovative method utilizing ultrasensitive spectrofluorimetry for the detection of centrophenoxine (CPX) drug. The employed methodology in this study involved the utilization of one-step, one-pot, and direct spectrofluorimetric technique, which was found to be both efficient and environmentally sustainable in the validation and assessment of the drug. Simply, when CPX and erythrosine B reagent were combined in an acidic environment, the highly resonance Rayleigh scattering product was immediately produced. The sensitivity limits were observed to be within the range of 15–47 ng mL−1, whereas the linearity was assessed to be in the range of 50–2000 ng mL−1. The optimal settings for all modifiable parameters of the system were ascertained through an analysis of centrophenoxine-erythrosine B complexes. Moreover, the system demonstrated compliance with International Council for Harmonization (ICH) specifications without encountering any issues. The suggested process was then rated on different recent environmental safety measuring metrics to see how good it was for the environment. Fortunately, the WAC standards that combine ecological and functional elements utilizing the Green/Red/Blue (RGB 12) design also acclaimed the current analytical technique as a white one. Additionally, a new applicability evaluation tool (BAGI) was employed to estimate the practicability of the planned method in the analytical chemistry field.