Clinical Trials That Have Informed the Modern Management of Breast Cancer

Randomized controlled trials have informed the historical evolution of breast cancer management, distilling operative and nonoperative treatments to achieve disease control and improve survival while maximizing quality of life and minimizing complications. The authors describe landmark trials invest...

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Bibliographic Details
Published in:	Surgical oncology clinics of North America Vol. 32; no. 1; pp. 27 - 46
Main Authors:	Krecko, Laura K., Lautner, Meeghan A., Wilke, Lee G.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-01-2023
Subjects:	Adjuvant Axilla Breast cancer Breast Neoplasms - surgery Chemotherapy Clinical trials Endocrine Female Humans Mastectomy Neoadjuvant Neoadjuvant Therapy Quality of Life Chemotherapy Clinical trials Axilla Neoadjuvant Endocrine Breast cancer Adjuvant
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Summary:	Randomized controlled trials have informed the historical evolution of breast cancer management, distilling operative and nonoperative treatments to achieve disease control and improve survival while maximizing quality of life and minimizing complications. The authors describe landmark trials investigating and influencing the following aspects of breast cancer care: extent of breast surgery; axillary management; neoadjuvant and adjuvant therapies; and selection of chemotherapy versus endocrine therapy via application of genomic assays.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	1055-3207 1558-5042
DOI:	10.1016/j.soc.2022.07.004