Persistent Infecton Uptake in an Infected Prosthetic Knee

• Published in: Clinical nuclear medicine Vol. 31; no. 3; pp. 149 - 150
• Main Authors: Adams, Bruce K, Youssef, Inas, El-Tom, El-Fatih Ahmed
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins, Inc 01-03-2006
• Subjects: Ciprofloxacin - analogs & derivatives; Ciprofloxacin - pharmacokinetics; Female; Humans; Knee Joint - diagnostic imaging; Knee Joint - surgery; Knee Prosthesis - adverse effects; Metabolic Clearance Rate; Middle Aged; Organotechnetium Compounds - pharmacokinetics; Prosthesis-Related Infections - diagnostic imaging; Prosthesis-Related Infections - etiology; Prosthesis-Related Infections - metabolism; Radionuclide Imaging; Radiopharmaceuticals - pharmacokinetics; Time Factors
• ISSN: 0363-9762; 1536-0229
• DOI: 10.1097/01.rlu.0000200785.86278.fe

A 62-year-old diabetic woman underwent a total knee replacement 2 months before presenting to the hospital with a swollen, red, painful left knee. Examination revealed cellulitis around the knee, tenderness, and limited range of movement. She ran a temperature, had a C-reactive protein of 60, white cell counts of 6 to 8 × 10/μL, an erythrocyte sedimentation rate of 120 mm/h, and a blood sugar of 157 mg/dL (normal range, 70–110 mg/dL). Bone scanning done to exclude bone involvement showed intense activity in the lateral condyle of the left femur, the tibial condyles, and patella. Infecton imaging of the left knee demonstrated increased periprosthetic uptake that persisted at 24 hours. The patient recovered after surgical debridement and intensive antibiotic treatment.