Indium(III) bromide catalyzed one-pot synthesis of trichloromethylated tetrahydropyrimidinones

[Display omitted] One-pot condensation of ethyl trichloroacetoacetate 1 with p-substituted aromatic aldehydes (Ph, 4-Me–C 6H 4, 4-Cl–C 6H 4, 4-MeO–C 6H 4) or furfural, and urea or thiourea catalyzed by indium(III) bromide affords eight trichloromethylated tetrahydropyrimidinones, in high yields....

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Bibliographic Details
Published in:	Tetrahedron letters Vol. 45; no. 49; pp. 8991 - 8994
Main Authors:	Martins, Marcos A.P., Teixeira, Marcos V.M., Cunico, Wilson, Scapin, Elisandra, Mayer, Rodrigo, Pereira, Claudio M.P., Zanatta, Nilo, Bonacorso, Helio G., Peppe, Clóvis, Yuan, Yao-Feng
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 29-11-2004
Subjects:	Biginelli reaction Indium(III) bromide Pyrimidinones Biginelli reaction Pyrimidinones Indium(III) bromide
Online Access:	Get full text
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Summary:	[Display omitted] One-pot condensation of ethyl trichloroacetoacetate 1 with p-substituted aromatic aldehydes (Ph, 4-Me–C 6H 4, 4-Cl–C 6H 4, 4-MeO–C 6H 4) or furfural, and urea or thiourea catalyzed by indium(III) bromide affords eight trichloromethylated tetrahydropyrimidinones, in high yields.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2004.10.048