Controversies about VEGF in type 2 diabetics with normo- and microalbuminuria

Controversies about VEGF in type 2 diabetics with normo- and microalbuminuria

Abstract We measured serum VEGF in type 2 diabetes, to correlate VEGF with the degree of albuminuria. Eighty-four diabetics were divided in normoalbuminuric (NAU ≤30 mg/24 h, n = 42) and microalbuminuric (MAU >30 and ≤300 mg/24 h, n = 42) subgroup. Forty-two age and sex matched blood donors were...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews Vol. 3; no. 3; pp. 176 - 177
Main Authors: Kubisz, Peter, Chudý, Peter, Staško, Ján, Hollý, Pavol, Galajda, Peter
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-09-2009
Subjects:
Endocrinology & Metabolism
Microalbuminuria
Type 2 diabetes mellitus
VEGF
VEGF
Microalbuminuria
Type 2 diabetes mellitus
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Summary:Abstract We measured serum VEGF in type 2 diabetes, to correlate VEGF with the degree of albuminuria. Eighty-four diabetics were divided in normoalbuminuric (NAU ≤30 mg/24 h, n = 42) and microalbuminuric (MAU >30 and ≤300 mg/24 h, n = 42) subgroup. Forty-two age and sex matched blood donors were in the control group. VEGF levels were measured using VEGF Quantikine, R&D Systems Inc., Minneapolis, MN kits, according to the manufacturer's recommendation. VEGF was significantly elevated in the NAU subgroup compared to controls (338.5, 202–432 pg/mL vs. 182, 124–211 pg/mL, respectively, p = 0.0443). VEGF could be a more sensitive predictor of renal changes than microalbuminuria.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2009.04.010