Genetic alterations in head and neck cancer

Mutations of the ras gene family appear to be an uncommon genetic alteration in SCCHN. A common region of DNA amplification on chromosome 11q13 has been identified in SCCHN. A cluster of proto-oncogenes (int-2, hst-1, bcl-1, prad-1) has been localized to the 11q13 region. Studies are needed to deter...

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Bibliographic Details
Published in:	Otolaryngologic clinics of North America Vol. 25; no. 5; p. 1065
Main Authors:	Somers, K D, Schechter, G L
Format:	Journal Article
Language:	English
Published:	United States 01-10-1992
Subjects:	Carcinoma, Squamous Cell - genetics Chromosomes, Human, Pair 11 Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor - genetics Head and Neck Neoplasms - genetics Humans Proto-Oncogenes - genetics Tumor Suppressor Protein p53 - genetics
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Summary:	Mutations of the ras gene family appear to be an uncommon genetic alteration in SCCHN. A common region of DNA amplification on chromosome 11q13 has been identified in SCCHN. A cluster of proto-oncogenes (int-2, hst-1, bcl-1, prad-1) has been localized to the 11q13 region. Studies are needed to determine the critical genes in 11q13 whose expression drive the amplicon. Mutations of the p53 tumor suppressor gene are the most common genetic alteration in SCCHN. The hope is that dysregulated oncogenes or tumor suppressor genes may be targets for specific therapy.
ISSN:	0030-6665
DOI:	10.1016/S0030-6665(20)30925-7