Pseudo‐pseudo Meigs syndrome in systemic lupus erythematosus misdiagnosed as pseudo‐Meigs' syndrome: A case report

• Published in: The journal of obstetrics and gynaecology research Vol. 49; no. 8; pp. 2199 - 2204
• Main Authors: He, Jiaqi, Li, Jinke, Fan, Bao, Yan, Liya, Ouyang, Ling
• Format: Journal Article
• Language: English
• Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01-08-2023; Wiley Subscription Services, Inc
• Subjects: Ascites; case report; Case reports; Fibroids; Lupus; Malignancy; Ovarian cancer; Pelvis; Pleural effusion; pseudo‐Meigs' syndrome; pseudo‐pseudo Meigs syndrome; Serological tests; Systemic lupus erythematosus; Tumors; case report; systemic lupus erythematosus; pseudo-Meigs' syndrome; pseudo-pseudo Meigs syndrome
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.15677

Symptoms of pelvic masses, elevated serum CA125 levels, massive ascites, and pleural effusion in female patients are usually associated with malignancy. Some benign ovarian tumors or other nonmalignant tumors may also produce similar symptoms, called Meigs syndrome or pseudo‐Meigs' syndrome, which should be one of the differential diagnoses. However, there is an extremely rare form of SLE called pseudo‐pseudo Meigs syndrome (PPMS), which may also present with the above symptoms, but is not associated with any of the tumors. In this paper, we report a case of a 47‐year‐old woman who presented with abdominal distention. The patient was found to have elevated serum CA125 levels to 182.9 U/mL before the operation. Her PET‐CT suggested a large heterogeneous mass in the pelvis measuring 8.2 × 5.8 cm with a large amount of ascites. She was initially diagnosed with ovarian cancer and underwent exploratory laparotomy. Pathology of the surgical specimen revealed a uterine leiomyoma. Two months after discharge, the patient's ascites reappeared along with recurrent intestinal obstruction. After ascites and serological tests, she was eventually diagnosed with systemic lupus erythematosus and received systemic hormonal therapy.