Genetics of autoreactive B cells

It is now well-accepted that autoimmune diseases develop as a result of interactions between a complex genetic basis and environmental triggers. Autoreactive B cells play a major role in many autoimmune diseases, by secreting autoantibodies or cytokines and/or presenting auto-antigens to T cells. St...

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Bibliographic Details
Published in:	Frontiers in bioscience Vol. 12; no. 1; pp. 1707 - 1721
Main Authors:	Xu, Zhiwei, Duan, Biyan, Morel, Laurence
Format:	Journal Article
Language:	English
Published:	United States 01-01-2007
Subjects:	Animals Autoantibodies - biosynthesis Autoimmune Diseases - genetics Autoimmunity B-Lymphocytes - immunology Chromosome Mapping Humans Mice Mice, Transgenic
Online Access:	Get full text
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Summary:	It is now well-accepted that autoimmune diseases develop as a result of interactions between a complex genetic basis and environmental triggers. Autoreactive B cells play a major role in many autoimmune diseases, by secreting autoantibodies or cytokines and/or presenting auto-antigens to T cells. Studies performed with human patients and murine models have accumulated evidence that B-cell autoreactivity, or its manifestation as the presence of autoantibodies, are also supported by multiple genetic determinants. These studies will be summarized in this review and presented in a critical perspective of the approaches used to obtain these results, and their significance for our understanding of B-cell tolerance.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1093-9946 1093-4715
DOI:	10.2741/2183