Myocarditis in connective tissue diseases: an often-overlooked clinical manifestation

• Published in: Rheumatology international Vol. 43; no. 11; pp. 1983 - 1992
• Main Authors: Azzam, Muayad, Awad, Amro, Abugharbyeh, Aya, Kahaleh, Bashar
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2023; Springer Nature B.V
• Subjects: Connective tissue diseases; Inflammatory diseases; Lupus; Medicine; Medicine & Public Health; Musculoskeletal diseases; Myocarditis; Review; Rheumatology; Myocarditis; Cardiac involvement; Myositis; Arthritis; Connective tissue diseases
• ISSN: 1437-160X; 0172-8172; 1437-160X
• DOI: 10.1007/s00296-023-05428-w

To discuss what is currently known about myocarditis in the context of major connective tissue diseases, including Systemic lupus erythematosus, Rheumatoid Arthritis, Sjogren, Dermato-myositis and Polymyositis, Systemic Sclerosis, and Mixed connective tissue disease. Variability exists between studies regarding the incidence of myocarditis in connective tissue diseases, which is hypothesized to be the result of its subclinical course in most cases. Extensive gaps of knowledge exist in the field of pathophysiology. Although endomyocardial biopsy remains to be the gold standard for diagnosis, the advancement in non-invasive modalities such as cardiac MRI, echocardiography, and nuclear medicine has allowed for earlier and more frequent detection of myocarditis. A lack of treatment guidelines was found across the different connective tissue diseases. Most of the literature available revolved around myocarditis in the context of Systemic lupus erythematosus. Numerous recent studies were published that contributed to advancements in diagnosis and treatment however, there remains a lack of diagnostic and treatment guidelines.