SARS-CoV-2 and the pancreas: What do we know about acute pancreatitis in COVID-19 positive patients?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause pancreatic damage, both directly to the pancreas via angiotensin-converting enzyme 2 receptors (the transmembrane proteins required for SARS-CoV-2 entry, which are highly expressed by pancreatic cells) and indirectly through loco...
Saved in:
| Published in: | World journal of gastroenterology : WJG Vol. 28; no. 36; pp. 5240 - 5249 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Baishideng Publishing Group Inc
28-09-2022
|
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause pancreatic damage, both directly to the pancreas
via
angiotensin-converting enzyme 2 receptors (the transmembrane proteins required for SARS-CoV-2 entry, which are highly expressed by pancreatic cells) and indirectly through locoregional vasculitis and thrombosis. Despite that, there is no clear evidence that SARS-CoV-2 is an etiological agent of acute pancreatitis. Acute pancreatitis in coronavirus disease 2019 (COVID-19) positive patients often recognizes biliary or alcoholic etiology. The prevalence of acute pancreatitis in COVID-19 positive patients is not exactly known. However, COVID-19 positive patients with acute pancreatitis have a higher mortality and an increased risk of intensive care unit admission and necrosis compared to COVID-19 negative patients. Acute respiratory distress syndrome is the most frequent cause of death in COVID-19 positive patients and concomitant acute pancreatitis. In this article, we reported recent evidence on the correlation between COVID-19 infection and acute pancreatitis. |
|---|---|
| Bibliography: | SourceType-Other Sources-1 content type line 63 ObjectType-Editorial-2 ObjectType-Commentary-1 Author contributions: Brisinda G and Chiarello MM equally contributed to the drafting of the manuscript and must both be considered first author; Chiarello MM and Brisinda G conceived the original idea; Tropeano G, Alteri G, Puccioni C, Fransvea P and Bianchi V performed a comprehensive review of all available literature and summarized the data; Brisinda G and Chiarello MM meet the criteria for authorship established by the International Committee of Medical Journal Editors and verify the validity of the results reported; and all authors read and approved the final manuscript. Corresponding author: Giuseppe Brisinda, MD, Professor, Surgeon, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Largo Agostino Gemelli 8, Rome 00168, Italy. gbrisin@tin.it |
| ISSN: | 1007-9327 2219-2840 |
| DOI: | 10.3748/wjg.v28.i36.5240 |