Ertapenem plus meropenem combination treatment in carbapenem-resistant Klebsiella pneumoniae bacteremia: an analysis of 53 cases

• Published in: European journal of clinical microbiology & infectious diseases Vol. 42; no. 10; pp. 1269 - 1273
• Main Authors: Önal, Uğur, Akyol, Deniz, Kaya, Arda, Başkol, Dilşah, Kenanoglu, Buse, Şanlıdağ, Gamze, Önal, Ayşe Uyan, Avşar, Cansu Bulut, Mert, Merve, Memetali, Seichan, Erdem, Hüseyin Aytaç, Bozkurt, Devrim, Şimşir, Adnan, Bozbıyık, Osman, Kahraman, Ümit, Özgiray, Erkin, Korkmaz, Pervin, Çilli, Feriha, Pullukçu, Hüsnü, Yamazhan, Tansu, Taşbakan, Meltem Işıkgöz, Arda, Bilgin, Ulusoy, Sercan, Sipahi, Oğuz Reşat
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-10-2023; Springer Nature B.V
• Subjects: Antibiotics; Bacteremia; Biomedical and Life Sciences; Biomedicine; Brief Report; Ertapenem; Hospitals; Infectious diseases; Internal Medicine; Klebsiella; Klebsiella pneumoniae; Medical Microbiology; Medicine; Meropenem; Microbiology; Mortality; Nosocomial infections; Reimbursement; Statistical analysis; Success; University faculty; Urinary tract; Urinary tract diseases; Urinary tract infections; Urogenital system; Double carbapenem therapy; Carbapenem-resistant; Bacteremia
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-023-04660-3

Herein, we aimed to describe the outcomes of patients with blood stream infections due to carbapenem-resistant
Klebsiella pneumoniae
(CR-Kp) who received ertapenem plus meropenem combination treatment (EMCT). A total of 53 patients with culture proven CR-Kp bacteremia treated with ertapenem + meropenem were included. The patients with secondary bacteremia due to urinary tract infection exhibited a significantly lower 1-month mortality (OMM), particularly in those with microbiological eradication and those with end-of-treatment success. Salvage EMCT resulted in 49% 1-month survival.