Potent inhibitors of neutral endopeptidase. 2-Biphenyl- methylglutaric acid amide derivatives

Potent inhibitors of neutral endopeptidase. 2-Biphenyl- methylglutaric acid amide derivatives

A series of glutaric acid amide derivatives were synthesized and tested for NEP inhibitory activity. Compounds 14a, 14b, 16a and 22, with a biphenylmethyl group at P′ 1 position, showed potent inhibitory activity. A series of glutaric acid amide derivatives were synthesized and tested for NEP inhibi...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters Vol. 6; no. 1; pp. 65 - 70
Main Authors: Kanno, Hideyuki, Osanai, Ken, Furugohri, Taketoshi, Watanabe, Yoshifumi
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-01-1996
Online Access:Get full text
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Summary:A series of glutaric acid amide derivatives were synthesized and tested for NEP inhibitory activity. Compounds 14a, 14b, 16a and 22, with a biphenylmethyl group at P′ 1 position, showed potent inhibitory activity. A series of glutaric acid amide derivatives were synthesized and tested for NEP inhibitory activity. Compounds 14a, 14b, 16a and 22, with a biphenylmethyl group at P1' position, showed potent inhibitory activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00551-4