Cultivation of exoerythrocytic stages of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui in Macaca mulatta hepatocytes

Exoerythrocytic stage parasites of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui were cultured by inoculating primary cultures of hepatocytes from Macaca mulatta with sporozoites. Less than 1% of inoculated sporozoites survived. Morphology and size of the liver stages in all 4 species...

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Bibliographic Details
Published in:	The American journal of tropical medicine and hygiene Vol. 39; no. 6; p. 529
Main Authors:	Millet, P, Fisk, T L, Collins, W E, Broderson, J R, Nguyen-Dinh, P
Format:	Journal Article
Language:	English
Published:	United States 01-12-1988
Subjects:	Animals Cells, Cultured Liver - cytology Liver - parasitology Macaca mulatta Plasmodium - growth & development
Online Access:	Get more information
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Summary:	Exoerythrocytic stage parasites of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui were cultured by inoculating primary cultures of hepatocytes from Macaca mulatta with sporozoites. Less than 1% of inoculated sporozoites survived. Morphology and size of the liver stages in all 4 species were similar to in vivo descriptions and the time required for in vitro maturation correlated well with prepatent periods described.
ISSN:	0002-9637
DOI:	10.4269/ajtmh.1988.39.529