Methyl ethers of prostaglandins F2 alpha and I2

• Published in: Prostaglandins and medicine Vol. 6; no. 4; p. 345
• Main Authors: Andersen, N H, Subramanian, N, De, B, McCrae, D A, Tynan, S S, Rao, C V
• Format: Journal Article
• Language: English
• Published: United States 01-04-1981
• Subjects: Animals; Blood Pressure - drug effects; Cattle; Circular Dichroism; Corpus Luteum - drug effects; Cricetinae; Dinoprost - analogs & derivatives; Epoprostenol - analogs & derivatives; Female; Gerbillinae; Isomerism; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Muscle, Smooth - drug effects; Platelet Aggregation - drug effects; Prostaglandins F, Synthetic - chemical synthesis; Prostaglandins F, Synthetic - pharmacology; Prostaglandins, Synthetic - chemical synthesis; Prostaglandins, Synthetic - pharmacology; Rabbits; Rats; Structure-Activity Relationship
• ISSN: 0161-4630
• DOI: 10.1016/0161-4630(81)90066-5

Regiospecific monomethyl prostaglandin f2 alpha ethers (at 0-9, 0-11, and 0-15) have been prepared by total synthesis. The 9, 15-bis-ether was also prepared. The 11- and 15-monoethers have been converted to the corresponding prostacyclins. Nuclear Magnetic Resonance (NMR) spectral comparisons indicate conformational changes associated with ether formation; nonetheless, the PGF2 alpha monoethers all retain significant biological activity: 3-420% of natural PGF2 alpha. The 9- and 15- menthyl ethers show increased selectivity for luteolytic activity as measured in the hamster antifertility (HAF) assay. In contrast the prostacyclin ethers are essentially devoid of agonist activity on both the platelet and vasculature. Prostacyclin diastereomers [5a] also lack activity and it appears that any modification at or of the C-11 or C-15 functions reduces receptor binding by at least a factor of 100.