Effects of N-methyl- and N-isobutyl-1,2-diphenyl ethanol amines on the spontaneous and evoked contractions in the rat isolated uterus

• Published in: General pharmacology Vol. 22; no. 4; p. 685
• Main Authors: el Tahir, K E, el Nasser, M A, Ageel, A M, el-Obeid, H A, al-Rashood, K A
• Format: Journal Article
• Language: English
• Published: England 1991
• Subjects: Animals; Calcium Channel Blockers - pharmacology; Calcium Chloride - pharmacology; Diltiazem - pharmacology; Dinoprostone - pharmacology; Embryo Implantation - drug effects; Embryonic and Fetal Development - drug effects; Ethanolamines - pharmacology; Female; In Vitro Techniques; Pregnancy; Rats; Rats, Inbred Strains; Uterine Contraction - drug effects
• ISSN: 0306-3623
• DOI: 10.1016/0306-3623(91)90078-K

1. The effects of N-methyl- and N-isobutyl-1,2-diphenyl ethanol amine (compounds M & E), respectively and diltiazem (D) were examined on the spontaneous and evoked uterine contractions of pregnant rats in vitro. 2. Addition of compound M (75-300 microM), compound E (15-60 microM) or D (100-400 nM) to the uterine tissues, inhibited the spontaneous contractions in a dose-dependent manner. The potency order was D greater than E greater than M. 3. The inhibitions were reversed by elevating the extracellular Ca2+ concentration by 20 mM. The compounds also antagonised CaCl2-evoked contractions. 4. Treatment of rats with either compound during pregnancy days (1-16) did not affect the implantation process and did not induce any teratogenicity. 5. The uterine inhibitory effects of the compounds may be due to blockade of uterine Ca2+ channels.