Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene

Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mR...

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Bibliographic Details
Published in:	DNA (New York, N.Y.) Vol. 6; no. 4; p. 283
Main Authors:	Gray, A, Tam, A W, Dull, T J, Hayflick, J, Pintar, J, Cavenee, W K, Koufos, A, Ullrich, A
Format:	Journal Article
Language:	English
Published:	United States 01-08-1987
Subjects:	Age Factors Animals Base Sequence Chromosome Mapping Fetus - physiology Gene Expression Regulation Humans Insulin-Like Growth Factor II - genetics Molecular Sequence Data Neoplasms - genetics Promoter Regions, Genetic Rats Repetitive Sequences, Nucleic Acid RNA Splicing RNA, Messenger - genetics Somatomedins - genetics Tissue Distribution Transcription, Genetic
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Summary:	Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5'-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.
ISSN:	0198-0238
DOI:	10.1089/dna.1987.6.283