Time to recovery from severe community-acquired pneumonia and its determinants among older adults admitted to North Wollo hospitals: A multi-centred cohort study

• Published in: Journal of global health Vol. 14; p. 04203
• Main Authors: Kitaw, Tegene Atamenta, Azmeraw, Molla, Temesgen, Dessie, Haile, Ribka Nigatu
• Format: Journal Article
• Language: English
• Published: Scotland Edinburgh University Global Health Society 27-09-2024; International Society of Global Health
• Subjects: Aged; Aged, 80 and over; Chronic obstructive pulmonary disease; Cohort analysis; Cohort Studies; Community-Acquired Infections - mortality; Data entry; Ethiopia - epidemiology; Fatalities; Female; Health care delivery; Hospitalization - statistics & numerical data; Hospitals; Humans; Low income areas; Male; Medical records; Mortality; Mortality risk; Older people; Patients; Pneumonia; Pneumonia - mortality; Population; Quality of life; Retrospective Studies; Risk Factors; Sampling techniques; Sociodemographics; Survival analysis; Time Factors; Variables; Ventilation; Ethiopia
• ISSN: 2047-2978; 2047-2986; 2047-2986
• DOI: 10.7189/jogh.14.04203

Severe community-acquired pneumonia presents a looming threat to older adults globally, often resulting in alarming mortality rates. Despite advancements in treatment, challenges persist, exacerbated by factors like increasing comorbidity. As age rises, so does the risk of mortality and prolonged recovery periods. Particularly in low-income countries such as Ethiopia, the burden of severe community-acquired pneumonia is staggering. Yet, research on the estimated time to recovery and its determinants among older adults in this region remains insufficient, demanding urgent attention. Hence, in this study we endeavour to uncover insights into the recovery time and contributing factors among older adults.
We conducted a multi-centred retrospective cohort study among 422 older adults aged >65 years. We collected data using a structured checklist, and the final sample was meticulously selected using a systematic sampling technique. We computed Kaplan-Meier survival curves and log-rank tests to compare survival curves. We assessed multicollinearity using variance inflation factors. Further, we employed a Cox regression model to identify significant determinants, with model fitness evaluated using a Cox-Snell residual plot. Statistical significance was declared at a P ≤ 0.05.
In this study, 79.3% (95% confidence interval (CI) = 75.58-83.29) of patients achieved recovery, with a median time to recovery from severe community-acquired pneumonia of 19 days. Age >75 years, diabetes mellitus, chronic obstructive pulmonary disease, elevated creatinine level and baseline white blood cells greater than 11.0 × 10
/L were found to be significant determinants.
On average, older adults take 19 days to recover from severe community-acquired pneumonia. Recovery times are notably longer for individuals aged >75 years, those with comorbidities, and those with elevated white blood cell and creatinine levels. Therefore, tailored interventions addressing these specific factors could potentially improve patient outcomes.