MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

• Published in: Natural product communications Vol. 9; no. 4; p. 505
• Main Authors: Kaya, Duygu, Jäger, Anna K, Yalçin, Funda N, Ersöz, Tayfun
• Format: Journal Article
• Language: English
• Published: United States 01-04-2014
• Subjects: Benzophenones - chemistry; Gentiana - chemistry; Glucosides - chemistry; Monoamine Oxidase - metabolism; Monoamine Oxidase Inhibitors - chemistry; Monoamine Oxidase Inhibitors - pharmacology
• ISSN: 1934-578X
• DOI: 10.1177/1934578X1400900420

Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H20 extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3'-dihydroxy-4-methoxy-benzophenone-6-O-beta-glucopyranoside (1), 2,4,3',4'-tetrahydroxy-benzophenone-6-O-beta-glucopyranoside (maclurin-6-O-f-glucopyranoside) (2) and 2,4,3'-trihydroxy-benzophenone-6-O-beta-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50 = 31.3 +/- 4 microM and 41 +/- 4.7 microM resp.).