Muscle GSH-Px activity after prolonged exercise, training, and selenium supplementation

• Published in: Biological trace element research Vol. 47; no. 1/3; pp. 279 - 285
• Main Authors: Tessier, F. (University of Nice, Nice, France.), Hida, H, Favier, A, Marconnet, P
• Format: Journal Article
• Language: English
• Published: United States 01-01-1995
• Subjects: ACTIVIDAD ENZIMATICA; ACTIVIDAD FISICA; ACTIVITE ENZYMATIQUE; ACTIVITE PHYSIQUE; Adult; ADULTE; ADULTOS; ADULTS; Analysis of Variance; ANIMAL PHYSIOLOGY; ANIMAL TISSUES; Biopsy, Needle; BLOOD PLASMA; COMPLEMENT ALIMENTAIRE; DURACION; DURATION; DUREE; ENDURANCE TESTING; ENSAYO; ENZYMIC ACTIVITY; Exercise; FISIOLOGIA ANIMAL; GLUTATHION PEROXYDASE; GLUTATHIONE PEROXIDASE; Glutathione Peroxidase - drug effects; Glutathione Peroxidase - metabolism; GLUTATION PEROXIDASA; HOMBRES; HOMME; Humans; Male; MEN; MINERAL NUTRIENTS; MUSCLE; Muscle, Skeletal - cytology; Muscle, Skeletal - drug effects; Muscle, Skeletal - enzymology; MUSCLES; MUSCULOS; NUTRIENTES MINERALES; PHYSICAL ACTIVITY; Physical Exertion; PHYSIOLOGIE ANIMALE; Placebos; PLASMA SANGUIN; PLASMA SANGUINEO; SELENIO; SELENIUM; Selenium - blood; Selenium - pharmacology; Space life sciences; SUBSTANCE NUTRITIVE MINERALE; SUPLEMENTOS; SUPPLEMENTS; TEJIDOS ANIMALES; TESTAGE; TESTING; TISSU ANIMAL; TOCOFEROLES; TOCOPHEROL; TOCOPHEROLS; Vitamin E - blood; YOUNG ADULTS
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/BF02790128

A double-blind study of the effects of supplementing with selenium vs. placebo on the physiological responses to acute and chronic exercise was conducted in 24 healthy, nonsmoking males, mean age 22.9 +/- 2.1 yr, randomly divided into two groups of 12 (Pla/Sel). After a controlled period in the absence of training, all subjects were put on an individualized endurance training program with the same rules of progression and overload (3 sessions/wk x 10 wk). Supplementation, either real (240 micrograms of organic selenium/d in Sel group) or imaginary (Pla group) was administered during the same period. In each of the conditions Pre- and Post- (training +/- sel supplementation), muscle, plasma, and systemic parameters were determined before (BF) and after (AF) acute exercise, involving the repetition of muscle work cycles separated by 5-min recovery periods, combining 20 min at 65% and a maximal duration of 100% VO2 max of running on a treadmill, leading the subjects to exhaustion between 2 h 40 min and 3 h 30 min. Changes in parameters as a function of three independent variables: 1. Acute exercise (E); 2. Chronic exercise (T); and 3. Selenium supplementing (S) were tested with ANOVA and the Student's t-test on paired series. Among the variables examined, muscle glutathione peroxidase (GPx) presented a remarkable behavior.