Platelet monoamine oxidase and erythrocyte catechol-o-methyltransferase activity in alcoholism and controlled abstinence

This study substantiates previous reports that low platelet monoamine oxidase (MAO) activity is associated with alcoholism. Catechol-o-methyltransferase (COMT) activity in erythrocytes of alcoholics did not differ from that of controls. In 20 male alcoholics low platelet MAO activity was found durin...

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Bibliographic Details
Published in:	Drug and alcohol dependence Vol. 12; no. 1; p. 85
Main Authors:	Agarwal, D P, Philippu, G, Milech, U, Ziemsen, B, Schrappe, O, Goedde, H W
Format:	Journal Article
Language:	English
Published:	Ireland 01-08-1983
Subjects:	Adult Alcoholism - enzymology Blood Platelets - enzymology Catechol O-Methyltransferase - blood Chemical and Drug Induced Liver Injury - enzymology Erythrocytes - enzymology Female Humans Male Middle Aged Monoamine Oxidase - blood Substance Withdrawal Syndrome - enzymology Tryptamines - blood Tyramine - blood
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Summary:	This study substantiates previous reports that low platelet monoamine oxidase (MAO) activity is associated with alcoholism. Catechol-o-methyltransferase (COMT) activity in erythrocytes of alcoholics did not differ from that of controls. In 20 male alcoholics low platelet MAO activity was found during the first 3 days after hospitalization. The MAO activity increased in the next 2 weeks of abstinence and then tended to decrease again.
ISSN:	0376-8716
DOI:	10.1016/0376-8716(83)90056-X