Effect of triacylglycerols on erythrocyte deformability in vitro

Effect of triacylglycerols on erythrocyte deformability in vitro

With Reid's filtration technique as a bioassay for evaluating red blood cell (RBC) deformability, we found that tripalmitolein, triolein and trilinolein improved the deformability of calcium-loaded RBC while glycerol, linoleic acid, dilinoleoyl phosphatidyl choline, trilpalmitin, tristearin, tr...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids Vol. 48; no. 5; p. 351
Main Authors: Hong, C Y, Lai, L J, Shiao, M S, Chiang, B N
Format: Journal Article
Language:English
Published: Scotland 01-05-1993
Subjects:
Dose-Response Relationship, Drug
Erythrocyte Deformability - drug effects
Humans
Triglycerides - pharmacology
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Summary:With Reid's filtration technique as a bioassay for evaluating red blood cell (RBC) deformability, we found that tripalmitolein, triolein and trilinolein improved the deformability of calcium-loaded RBC while glycerol, linoleic acid, dilinoleoyl phosphatidyl choline, trilpalmitin, tristearin, trilinolenin and triarachidonin did not. Maximal effect of tripalmitolein, triolein and trilinolein was achieved at 10(-9), 10(-10) and 10(-8) M respectively. We propose that only those triacylglycerols which contain fatty acids with one or two double bonds could modify RBC membrane fluidity and improve RBC deformability.
ISSN:0952-3278
DOI:10.1016/0952-3278(93)90114-C