Effect of antagonists of serotonin receptors on modulation with serotonin of synaptic activity of projectional neurons of rat amygdala dorsolateral nucleus

• Published in: Journal of evolutionary biochemistry and physiology Vol. 48; no. 5-6; pp. 523 - 528
• Main Authors: Masalov, I. S., Tsvetkov, E. A., Lokshina, E. I., Vesselkin, N. P.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01-09-2012; Springer Nature B.V
• Subjects: Animal Physiology; Antagonist drugs; Biochemistry; Biomedical and Life Sciences; Brain; Comparative and Ontogenic Physiology; Evolutionary Biology; Life Sciences; Neurobiology; Neurons; Rodents; Serotonin; Projectional Neuron; Evolutionary Biochemistry; Carbogen; Picrotoxin; CNQX
• ISSN: 0022-0930; 1608-3202
• DOI: 10.1134/S0022093012050064

The work studies role of different receptor types of serotonin (5-hydroxytryptamine; 5-HT) in the process of synaptic activity modulation with 5-HT of rat dorsolateral amygdala projection neurons. The selective antagonist of 5-HT
1,2
receptors methylsergid maleate was shown to suppress the 5-HT inhibitory action on amplitude of the postsynaptic currents evoked by glutamate and GABA, whereas the antagonist of 5-HT
3,4
receptors SDZ202-557 produced no effect on the above-mentioned 5-HT action. The obtained action indicates that the 5-HT modulatory effect on the projectional neuron synaptic inputs is mediated by 5-HT receptors of the 1 and 2 types.