Rapidly growing, multifocal, benign choroid plexus tumor in an infant: case report

• Published in: Journal of neurosurgery. Pediatrics Vol. 23; no. 5; pp. 622 - 627
• Main Authors: Misiolek, Kalina A, Osborn, Zachary G, Hauser, Natalie, Thomas, Diana, Goodman, Jessica F, Fulkerson, Daniel H
• Format: Journal Article
• Language: English
• Published: United States 01-05-2019
• Subjects: infant; atypical; Aicardi syndrome; oncology; papilloma; choroid plexus
• ISSN: 1933-0707; 1933-0715; 1933-0715
• DOI: 10.3171/2018.12.PEDS18453

Choroid plexus papillomas (CPPs) are rare, benign tumors that can arise in young children. Most pediatric patients present with signs of hydrocephalus and require immediate treatment. The natural history of choroid plexus tumors in children without hydrocephalus is poorly defined. In this report, the authors present the very rare case of a child without hydrocephalus but with two intraventricular choroid plexus tumors discovered shortly after birth. Initial imaging had been performed for seizures and showed agenesis of the corpus callosum and enhancing tumors in the third and left lateral ventricles. Sequential imaging demonstrated rapid growth of both tumors. The lateral tumor was removed when the child was 3 months of age. A histological examination of the specimen showed benign features with an elevated mitotic rate. Given the patient's age of under 3 years, the diagnosis was WHO grade I CPP. The third ventricle tumor grew rapidly. A second surgery was performed and this tumor was resected. Again, the pathological diagnosis was WHO grade I CPP. The authors present this rare case and discuss the current relevant literature.