Successful High-dose Chemotherapy in Combination With Autologous Peripheral Blood Stem Cell Transplantation in an Anuric Child With Neuroblastoma

• Published in: Journal of pediatric hematology/oncology Vol. 43; no. 8; pp. e1156 - e1158
• Main Authors: Inoguchi, Tomohiro, Hamada, Riku, Kubota, Wataru, Terano, Chikako, Harada, Ryoko, Honda, Masataka, Yamaoka, Shoko, Yokokawa, Yuichi, Yuza, Yuki, Hataya, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01-11-2021
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Anuria - etiology; Anuria - pathology; Anuria - therapy; Child, Preschool; Combined Modality Therapy; Humans; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - pathology; Kidney Failure, Chronic - therapy; Male; Neuroblastoma - complications; Neuroblastoma - pathology; Neuroblastoma - therapy; Peripheral Blood Stem Cell Transplantation - adverse effects; Peripheral Blood Stem Cell Transplantation - methods; Prognosis; Renal Dialysis - methods; Transplantation, Autologous
• ISSN: 1077-4114; 1536-3678
• DOI: 10.1097/MPH.0000000000002090

No reports describe high-dose chemotherapy (HDCT) with autologous peripheral blood stem cell transplantation (auto-PBSCT) in pediatric patients with neuroblastoma and end-stage renal disease. Here, we report the case of a patient with high-risk neuroblastoma who developed anuria during treatment. HDCT with auto-PBSCT under hemodialysis, with strict attention to the ultrafiltration volume and dose modification of alkylating agents, was performed. Although the first auto-PBSCT led to engraftment failure, the second auto-PBSCT resulted in successful myeloid engraftment 8 months after anuria. This case demonstrated that HDCT with auto-PBSCT can be safely performed in children with renal failure under hemodialysis.