Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent

Iron oxide nanoparticles have been one of the most widely used nanomaterials in biomedical applications. However, the incomplete understanding of the toxicity mechanisms limits their use in diagnosis and treatment processes. Many parameters are associated with their toxicity such as size, surface mo...

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Bibliographic Details
Published in:	Nanotechnology Vol. 34; no. 14
Main Authors:	Bozoglu, Serdar, Arvas, Melih Besir, Varlı, Hanife Sevgi, Ucar, Burcu, Acar, Tayfun, Karatepe, Nilgün
Format:	Journal Article
Language:	English
Published:	England 25-01-2023
Subjects:	Animals Ferric Compounds - chemistry Magnetic Iron Oxide Nanoparticles Magnetite Nanoparticles - chemistry Mice Precision Medicine Serum Albumin Spectroscopy, Fourier Transform Infrared surface coatings perfusion magnetic nanoparticles cytotoxicity nanoparticle stability
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Summary:	Iron oxide nanoparticles have been one of the most widely used nanomaterials in biomedical applications. However, the incomplete understanding of the toxicity mechanisms limits their use in diagnosis and treatment processes. Many parameters are associated with their toxicity such as size, surface modification, solubility, concentration and immunogenicity. Further research needs to be done to address toxicity-related concerns and to increase its effectiveness in various applications. Herein, colloidally stable nanoparticles were prepared by coating magnetic iron oxide nanoparticles (MIONPs) with protocatechuic acid (PCA) which served as a stabilizer and a linkage for a further functional layer. A new perfusion agent with magnetic imaging capability was produced by the adsorption of biocompatible passivating agent macro-aggregated albumin (MAA) on the PCA-coated MIONPs. PCA-coated MIONPs were investigated using infrared spectroscopy, thermogravimetric analysis and dynamic light scattering while adsorption of MAA was analysed by transmission electron microscopy, Fourier-transform infrared spectroscopy and x-ray diffraction methods. Magnetic measurements of samples indicated that all samples showed superparamagnetic behaviour. Cytotoxicity results revealed that the adsorption of MAA onto PCA-coated MIONPs provided an advantage by diminishing their toxicity against the L929 mouse fibroblast cell line compared to bare Fe O .
ISSN:	1361-6528
DOI:	10.1088/1361-6528/acb15b