Clinical, Pathological And İmmunohistochemical Findings Of Bovine Cutaneous Papillomatosis

• Published in: Veteriner Fakültesi dergisi Vol. 58; no. 3; pp. 161 - 165
• Main Authors: Özsoy,Şule Yurdagül, Özyıldız,Zafer
• Format: Journal Article
• Language: English
• Published: Ankara Üniversitesi Veteriner Fakültesi 01-01-2011; Ankara Üniversitesi
• Subjects: Sağlık Hizmetleri; Tıp; Ankara; Türkiye; Ki-67; PCNA; BPV-1; Sığır papillomatozis; Bovine papillomatosis
• ISSN: 1300-0861; 1308-2817
• DOI: 10.1501/vetfak_0000002468

Bovine cutaneous papillomatosis caused by a bovine papillomavirus, is a common skin disease in Turkey. The aim of the present study was to describe the clinical, histopathological and immunohistochemical aspects of naturally occurring bovine cutaneous papillomatosis. A total of 82 Holstein cattle (9.5%), aged between 5 and 24 months, were diagnosed as cutaneous papilloma by clinical examination. The percentage of papilloma and papillomatosis in male and female was found in 7.3% and 14.8%, respectively. The cauliflower-like growths of varying sizes (0.5-11 cm) were mostly located on the head (63.2%). Histopathology revealed various degrees of acanthosis and hyperkeratosis in all neoplasms. Immunohistochemical (IHC) examination with antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 were detected in the basal layer of the epidermis and connective tissue. Bovine papillomavirus (BPV-1) antigens were detected in the basal layer. In conclusion, it was decided that the BPV-1, PCNA and Ki-67 antibodies were very useful markers in the diagnosis of bovine cutaneous papilloma.