Exploring the Correlation Between Influenza A Virus (H3N2) Infections and Neurological Manifestations: A Scoping Review

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 3; p. e36936
• Main Authors: Reddy, Mithun K, Ca, Jayashankar, Kandi, Venkataramana, Murthy, Pooja M, Harikrishna, Ganaraja V, Reddy, Snigdha, Gr, Manish, Sam, Koshy, Challa, Sai Teja
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 30-03-2023; Cureus
• Subjects: Avian flu; Bird migration; Brain; Cytokine storm; Encephalitis; Epidemics; Experiments; Fever; Glycoproteins; Guillain-Barre syndrome; Hypoxia; Immune system; Infections; Infectious Disease; Inflammation; Kinases; Metabolism; Mutation; Neurology; Pandemics; Pathogenesis; Patients; Poultry; Swine flu; Vaccines; Viruses; Wildfowl; Europe; China; Japan; encephalitis; febrile convulsions; neurological manifestations; influenza a virus; h3n2
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.36936

Influenza A virus (IAV), particularly the H3N2 variant, is known to cause respiratory manifestations, but it can also lead to neurological complications ranging from mild symptoms like headache and dizziness to severe conditions such as encephalitis and acute necrotizing encephalopathy (ANE). In this article, the correlation between the H3N2 variant of the IAV and neurological manifestations is discussed. Additionally, prompt recognition and treatment of influenza-associated neurological manifestations are highlighted to prevent infection-related long-term complications. This review briefly discusses various neurological complications linked to IAV infections, such as encephalitis, febrile convulsions, and acute disseminated encephalomyelitis, and the potential mechanisms involved in the development of neurological complications.