Lipid infusion in critically ill patients. Acute effects on hemodynamics and pulmonary gas exchange

• Published in: Critical care medicine Vol. 9; no. 1; p. 27
• Main Authors: Järnberg, P O, Lindholm, M, Eklund, J
• Format: Journal Article
• Language: English
• Published: United States 01-01-1981
• Subjects: Adolescent; Adult; Carbon Dioxide - blood; Carbon Dioxide - physiology; Critical Care; Female; Hemodynamics; Humans; Lipids - therapeutic use; Male; Oxygen - blood; Oxygen Consumption; Pulmonary Diffusing Capacity; Respiratory Therapy; Triglycerides - blood
• ISSN: 0090-3493
• DOI: 10.1097/00003246-198101000-00007

Hemodynamics, pulmonary diffusing capacity (DLCO) blood gases, oxygen consumption (VO2) and carbon dioxide excretion (VCO2) were studied in healthy volunteers and ventilator-treated, critically ill patients before and during infusion of lipid emulsion for 4 h. Triglyceride levels rose from 1.0 mmole/L to 8.5 mmole/L in the volunteers and from 1.4 mmole/L to 6.3 mmole/L in the patients after h. No adverse effects on cardiovascular performance were observed. Increases in VO2, and VCO2 and cardiac output were found in both groups, while RQ remained constant. No changes in DLCO and blood gases occurred.