TI-201 SPECT in Pseudotumoral Multiple Sclerosis

• Published in: Clinical nuclear medicine Vol. 24; no. 3; pp. 186 - 188
• Main Authors: OBACH, VICTOR, GONZALEZ-MENACHO, JORDI, VIDAL, SERGI, LOMEÑA, FRANCESC, GRAUS, FRANCESC
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Lippincott Williams & Wilkins, Inc 01-03-1999; Hagerstown, MD Lippincott
• Subjects: Biological and medical sciences; Brain - diagnostic imaging; Brain Neoplasms - diagnostic imaging; Diagnosis, Differential; Humans; Male; Medical sciences; Middle Aged; Multiple Sclerosis - diagnostic imaging; Neurology; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Tumors of the nervous system. Phacomatoses; Radionuclide study; Pseudotumor; Thallium; Nervous system diseases; Multiple sclerosis; Central nervous system; Nuclear magnetic resonance imaging; Photon; Differential diagnostic; Inflammatory disease; Case study; Central nervous system disease; Distribution; Medical imagery; Tumor; Emission tomography
• ISSN: 0363-9762; 1536-0229
• DOI: 10.1097/00003072-199903000-00011

A patient with multiple sclerosis had a pseudotumoral plaque evident on a brain MRI that was indistinguishable from a malignant brain tumor. TI-201 SPECT showed uptake of TI-201 in the lesion with indices of 1.55 and 1.96 at 30 minutes and 3 hours, respectively. The retention index was 26.4%. The patient had clinical and radiologic spontaneous improvement, and the results of TI-201 SPECT performed 3 months later were negative. TI-201 uptake in multiple sclerosis pseudotumoral plaques has not been described before. In this patient, TI-201 SPECT could not differentiate a large multiplesclerosis plaque from a malignant brain tumor.