Chiari I malformation and idiopathic growth hormone deficiency in siblings

The authors report a case of three brothers. Two of these siblings presented with congenital growth hormone deficiency and Chiari I malformation. The third and younger brother has been found not to have growth hormone deficiency or the Chiari I malformation. Sparse cases of these two clinical occurr...

Full description

Saved in:

Bibliographic Details
Published in:	Child's nervous system Vol. 22; no. 6; pp. 632 - 634
Main Authors:	Murphy, R L, Tubbs, R S, Grabb, P A, Oakes, W J
Format:	Journal Article
Language:	English
Published:	Germany 01-06-2006
Subjects:	Arnold-Chiari Malformation - complications Arnold-Chiari Malformation - pathology Arnold-Chiari Malformation - surgery Child Child, Preschool Growth Hormone - deficiency Humans Magnetic Resonance Imaging - methods Male Phospholipids - metabolism Siblings Spinal Cord - pathology Spinal Cord - surgery
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The authors report a case of three brothers. Two of these siblings presented with congenital growth hormone deficiency and Chiari I malformation. The third and younger brother has been found not to have growth hormone deficiency or the Chiari I malformation. Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa has been determined to be altered in patients with Chiari I malformation and growth hormone deficiency. Our current case reports strengthen the association between these two pathological entities and are, to our knowledge, the first description of both defects in siblings.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0256-7040 1433-0350
DOI:	10.1007/s00381-005-0041-z